diff --git a/package/python-hyperframe/Config.in b/package/python-hyperframe/Config.in
index f3318a20e2..30457fe86e 100644
--- a/package/python-hyperframe/Config.in
+++ b/package/python-hyperframe/Config.in
@@ -1,6 +1,7 @@
 config BR2_PACKAGE_PYTHON_HYPERFRAME
 	bool "python-hyperframe"
+	depends on BR2_PACKAGE_PYTHON3
 	help
 	  HTTP/2 framing layer for Python.
 
-	  http://hyper.rtfd.org
+	  https://github.com/python-hyper/hyperframe/
diff --git a/package/python-hyperframe/python-hyperframe.hash b/package/python-hyperframe/python-hyperframe.hash
index 3e686a4aa2..b39ab51a72 100644
--- a/package/python-hyperframe/python-hyperframe.hash
+++ b/package/python-hyperframe/python-hyperframe.hash
@@ -1,5 +1,5 @@
 # md5, sha256 from https://pypi.org/pypi/hyperframe/json
-md5	6919183242feb26d8bce3b4cba81defd  hyperframe-5.2.0.tar.gz
-sha256	a9f5c17f2cc3c719b917c4f33ed1c61bd1f8dfac4b1bd23b7c80b3400971b41f  hyperframe-5.2.0.tar.gz
+md5  153c064e8ac654aaf136b3388c36de48  hyperframe-6.0.1.tar.gz
+sha256  ae510046231dc8e9ecb1a6586f63d2347bf4c8905914aa84ba585ae85f28a914  hyperframe-6.0.1.tar.gz
 # Locally computed sha256 checksums
-sha256	763a9342a04df62046c9dc748a5287934eb0a5331c6863b3ca0aee20e18cb4ed  LICENSE
+sha256  763a9342a04df62046c9dc748a5287934eb0a5331c6863b3ca0aee20e18cb4ed  LICENSE
diff --git a/package/python-hyperframe/python-hyperframe.mk b/package/python-hyperframe/python-hyperframe.mk
index 7640ade5fd..4b13ca51a3 100644
--- a/package/python-hyperframe/python-hyperframe.mk
+++ b/package/python-hyperframe/python-hyperframe.mk
@@ -4,9 +4,9 @@
 #
 ################################################################################
 
-PYTHON_HYPERFRAME_VERSION = 5.2.0
+PYTHON_HYPERFRAME_VERSION = 6.0.1
 PYTHON_HYPERFRAME_SOURCE = hyperframe-$(PYTHON_HYPERFRAME_VERSION).tar.gz
-PYTHON_HYPERFRAME_SITE = https://files.pythonhosted.org/packages/e6/7f/9a4834af1010dc1d570d5f394dfd9323a7d7ada7d25586bd299fc4cb0356
+PYTHON_HYPERFRAME_SITE = https://files.pythonhosted.org/packages/5a/2a/4747bff0a17f7281abe73e955d60d80aae537a5d203f417fa1c2e7578ebb
 PYTHON_HYPERFRAME_SETUP_TYPE = setuptools
 PYTHON_HYPERFRAME_LICENSE = MIT
 PYTHON_HYPERFRAME_LICENSE_FILES = LICENSE