diff --git a/package/python-setuptools/Config.in b/package/python-setuptools/Config.in
index f203d0f814..28228534f8 100644
--- a/package/python-setuptools/Config.in
+++ b/package/python-setuptools/Config.in
@@ -1,9 +1,7 @@
 config BR2_PACKAGE_PYTHON_SETUPTOOLS
 	bool "python-setuptools"
-	select BR2_PACKAGE_PYTHON_ZLIB if BR2_PACKAGE_PYTHON # runtime
-	select BR2_PACKAGE_PYTHON3_ZLIB if BR2_PACKAGE_PYTHON3 # runtime
-	select BR2_PACKAGE_PYTHON_PYEXPAT if BR2_PACKAGE_PYTHON # runtime
-	select BR2_PACKAGE_PYTHON3_PYEXPAT if BR2_PACKAGE_PYTHON3 # runtime
+	select BR2_PACKAGE_PYTHON3_ZLIB # runtime
+	select BR2_PACKAGE_PYTHON3_PYEXPAT # runtime
 	help
 	  Download, build, install, upgrade, and uninstall Python
 	  packages.
diff --git a/package/python-setuptools/python-setuptools.mk b/package/python-setuptools/python-setuptools.mk
index 8bca852fe2..04b872fb79 100644
--- a/package/python-setuptools/python-setuptools.mk
+++ b/package/python-setuptools/python-setuptools.mk
@@ -4,19 +4,11 @@
 #
 ################################################################################
 
-# For the target variant, we adapt the version depending on whether
-# Python 3.x or 2.x is selected for the target.
-ifeq ($(BR2_PACKAGE_PYTHON3),y)
 # Please keep in sync with
 # package/python3-setuptools/python3-setuptools.mk
 PYTHON_SETUPTOOLS_VERSION = 60.7.0
 PYTHON_SETUPTOOLS_SOURCE = setuptools-$(PYTHON3_SETUPTOOLS_VERSION).tar.gz
 PYTHON_SETUPTOOLS_SITE = https://files.pythonhosted.org/packages/29/dd/48d662bb93e5e51e72265ef612f869947d4ae4126328d7156824cd50d440
-else # Python
-PYTHON_SETUPTOOLS_VERSION = 44.0.0
-PYTHON_SETUPTOOLS_SOURCE = setuptools-$(PYTHON_SETUPTOOLS_VERSION).zip
-PYTHON_SETUPTOOLS_SITE = https://files.pythonhosted.org/packages/b0/f3/44da7482ac6da3f36f68e253cb04de37365b3dba9036a3c70773b778b485
-endif
 
 # The host variant is only for Python 2.x, so we need to use 44.0.0.
 HOST_PYTHON_SETUPTOOLS_VERSION = 44.0.0
@@ -30,14 +22,6 @@ PYTHON_SETUPTOOLS_CPE_ID_VENDOR = python
 PYTHON_SETUPTOOLS_CPE_ID_PRODUCT = setuptools
 PYTHON_SETUPTOOLS_SETUP_TYPE = setuptools
 
-ifeq ($(BR2_PACKAGE_PYTHON),y)
-define PYTHON_SETUPTOOLS_EXTRACT_CMDS
-	$(UNZIP) -d $(@D) $(PYTHON_SETUPTOOLS_DL_DIR)/$(PYTHON_SETUPTOOLS_SOURCE)
-	mv $(@D)/setuptools-$(PYTHON_SETUPTOOLS_VERSION)/* $(@D)
-	$(RM) -r $(@D)/setuptools-$(PYTHON_SETUPTOOLS_VERSION)
-endef
-endif
-
 define HOST_PYTHON_SETUPTOOLS_EXTRACT_CMDS
 	$(UNZIP) -d $(@D) $(HOST_PYTHON_SETUPTOOLS_DL_DIR)/$(HOST_PYTHON_SETUPTOOLS_SOURCE)
 	mv $(@D)/setuptools-$(HOST_PYTHON_SETUPTOOLS_VERSION)/* $(@D)