diff --git a/package/mpir/mpir.mk b/package/mpir/mpir.mk
index 03f21d892a..697e838114 100644
--- a/package/mpir/mpir.mk
+++ b/package/mpir/mpir.mk
@@ -31,4 +31,9 @@ ifeq ($(BR2_mips_32r6)$(BR2_mips_64r6),y)
 MPIR_CONF_ENV += MPN_PATH="generic"
 endif
 
+# Optimized powerpc64 code is not suitable for powerpc64le
+ifeq ($(BR2_powerpc64le),y)
+MPIR_CONF_ENV += MPN_PATH="generic"
+endif
+
 $(eval $(autotools-package))