diff --git a/package/oprofile/Config.in b/package/oprofile/Config.in
index 9cf569383b..7a88e4a87a 100644
--- a/package/oprofile/Config.in
+++ b/package/oprofile/Config.in
@@ -7,7 +7,8 @@ config BR2_PACKAGE_OPROFILE
 	depends on BR2_INSTALL_LIBSTDCPP
 	depends on !BR2_aarch64 && !BR2_nios2 # binutils
 	depends on BR2_USE_WCHAR # binutils
-	depends on !BR2_xtensa
+	# no memory barrier functions
+	depends on !BR2_xtensa && !BR2_microblaze
 	# libpfm4 is needed on PowerPC, and requires thread support
 	depends on BR2_TOOLCHAIN_HAS_THREADS_NPTL || !BR2_powerpc
 	help
@@ -28,7 +29,7 @@ config BR2_PACKAGE_OPROFILE
 
 comment "oprofile needs a toolchain w/ C++, wchar"
 	depends on BR2_USE_MMU
-	depends on !BR2_aarch64 && !BR2_nios2 && !BR2_xtensa
+	depends on !BR2_aarch64 && !BR2_nios2 && !BR2_xtensa && !BR2_microblaze
 	depends on !BR2_INSTALL_LIBSTDCPP || !BR2_USE_WCHAR
 
 comment "oprofile needs a toolchain w/ NPTL on PPC"