diff --git a/DEVELOPERS b/DEVELOPERS
index 531839c817..23ed6c8487 100644
--- a/DEVELOPERS
+++ b/DEVELOPERS
@@ -779,6 +779,7 @@ F:	package/gstreamer1/gst1-plugins-bayer2rgb-neon/
 
 N:	Emile Cormier <emile.cormier.jr@gmail.com>
 F:	package/python-appdirs/
+F:	package/python-zlmdb/
 
 N:	Eric Le Bihan <eric.le.bihan.dev@free.fr>
 F:	docs/manual/adding-packages-meson.txt
diff --git a/package/Config.in b/package/Config.in
index 2e1bf500e0..a09ad342d9 100644
--- a/package/Config.in
+++ b/package/Config.in
@@ -1327,6 +1327,7 @@ menu "External python modules"
 	source "package/python-yatl/Config.in"
 	source "package/python-zc-lockfile/Config.in"
 	source "package/python-zeroconf/Config.in"
+	source "package/python-zlmdb/Config.in"
 	source "package/python-zope-interface/Config.in"
 	source "package/python-zopfli/Config.in"
 endmenu
diff --git a/package/python-zlmdb/Config.in b/package/python-zlmdb/Config.in
new file mode 100644
index 0000000000..ac4ee05442
--- /dev/null
+++ b/package/python-zlmdb/Config.in
@@ -0,0 +1,22 @@
+config BR2_PACKAGE_PYTHON_ZLMDB
+	bool "python-zlmdb"
+	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS # python-numpy
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL # python-numpy
+	select BR2_PACKAGE_PYTHON_CBOR2 # runtime
+	select BR2_PACKAGE_PYTHON_CFFI # runtime
+	select BR2_PACKAGE_PYTHON_CLICK # runtime
+	select BR2_PACKAGE_PYTHON_FLATBUFFERS # runtime
+	select BR2_PACKAGE_PYTHON_LMDB # runtime
+	select BR2_PACKAGE_PYTHON_NUMPY # runtime
+	select BR2_PACKAGE_PYTHON_PYNACL # runtime
+	select BR2_PACKAGE_PYTHON_PYYAML # runtime
+	select BR2_PACKAGE_PYTHON_TXAIO # runtime
+	help
+	  Object-relational zero-copy in-memory database layer for
+	  LMDB.
+
+	  https://github.com/crossbario/zlmdb
+
+comment "python-zlmdb needs glibc or musl"
+	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS
+	depends on !(BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL)
diff --git a/package/python-zlmdb/python-zlmdb.hash b/package/python-zlmdb/python-zlmdb.hash
new file mode 100644
index 0000000000..d98dc7d12a
--- /dev/null
+++ b/package/python-zlmdb/python-zlmdb.hash
@@ -0,0 +1,5 @@
+# md5, sha256 from https://pypi.org/pypi/zlmdb/json
+md5  d730a394b74108933a65c9fbe76aba36  zlmdb-22.3.1.tar.gz
+sha256  0d416a47b1ee627186af8e5c99e5246f6b277df44ba5c6bb67e947eabf948e5a  zlmdb-22.3.1.tar.gz
+# Locally computed sha256 checksums
+sha256  8a139bf325dcca11e0e476ce537bf791a6cfbeed8899a9b6ddc55238e180d230  LICENSE
diff --git a/package/python-zlmdb/python-zlmdb.mk b/package/python-zlmdb/python-zlmdb.mk
new file mode 100644
index 0000000000..a040622d9d
--- /dev/null
+++ b/package/python-zlmdb/python-zlmdb.mk
@@ -0,0 +1,14 @@
+################################################################################
+#
+# python-zlmdb
+#
+################################################################################
+
+PYTHON_ZLMDB_VERSION = 22.3.1
+PYTHON_ZLMDB_SOURCE = zlmdb-$(PYTHON_ZLMDB_VERSION).tar.gz
+PYTHON_ZLMDB_SITE = https://files.pythonhosted.org/packages/71/87/bb3cebd5312e670e33551317c7fc5e4b6a4a9af39075a71cd541b32cc0bf
+PYTHON_ZLMDB_SETUP_TYPE = setuptools
+PYTHON_ZLMDB_LICENSE = MIT
+PYTHON_ZLMDB_LICENSE_FILES = LICENSE
+
+$(eval $(python-package))