diff --git a/package/pkg-python.mk b/package/pkg-python.mk
index 85374ae8bb..28ee4cb85f 100644
--- a/package/pkg-python.mk
+++ b/package/pkg-python.mk
@@ -109,6 +109,18 @@ HOST_PKG_PYTHON_SETUPTOOLS_INSTALL_OPTS = \
 	--root=/ \
 	--single-version-externally-managed
 
+# Target setuptools-rust-based packages
+PKG_PYTHON_SETUPTOOLS_RUST_ENV = \
+	$(PKG_PYTHON_SETUPTOOLS_ENV) \
+	$(PKG_CARGO_ENV) \
+	PYO3_CROSS_LIB_DIR="$(STAGING_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)"
+
+# Host setuptools-rust-based packages
+HOST_PKG_PYTHON_SETUPTOOLS_RUST_ENV = \
+	$(HOST_PKG_PYTHON_SETUPTOOLS_ENV) \
+	$(HOST_PKG_CARGO_ENV) \
+	PYO3_CROSS_LIB_DIR="$(HOST_DIR)/lib/python$(PYTHON3_VERSION_MAJOR)"
+
 # Target pep517-based packages
 PKG_PYTHON_PEP517_ENV = \
 	$(PKG_PYTHON_ENV)
@@ -146,6 +158,18 @@ HOST_PKG_PYTHON_PEP517_INSTALL_OPTS = \
 HOST_PKG_PYTHON_PEP517_BOOTSTRAP_INSTALL_OPTS = \
 	--installdir=$(HOST_DIR)/lib/python$(PYTHON3_VERSION_MAJOR)/site-packages
 
+# Target maturin packages
+PKG_PYTHON_MATURIN_ENV = \
+	$(PKG_PYTHON_PEP517_ENV) \
+	$(PKG_CARGO_ENV) \
+	PYO3_CROSS_LIB_DIR="$(STAGING_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)"
+
+# Host maturin packages
+HOST_PKG_PYTHON_MATURIN_ENV = \
+	$(HOST_PKG_PYTHON_PEP517_ENV) \
+	$(HOST_PKG_CARGO_ENV) \
+	PYO3_CROSS_LIB_DIR="$(HOST_DIR)/lib/python$(PYTHON3_VERSION_MAJOR)"
+
 ################################################################################
 # inner-python-package -- defines how the configuration, compilation
 # and installation of a Python package should be done, implements a
@@ -184,25 +208,41 @@ $(2)_BASE_BUILD_CMD   = setup.py build
 $(2)_BASE_INSTALL_CMD = setup.py install $$(HOST_PKG_PYTHON_DISTUTILS_INSTALL_OPTS)
 endif
 # Setuptools
-else ifeq ($$($(2)_SETUP_TYPE),setuptools)
+else ifneq ($$(filter setuptools setuptools-rust,$$($(2)_SETUP_TYPE)),)
 ifeq ($(4),target)
+ifeq ($$($(2)_SETUP_TYPE),setuptools-rust)
+$(2)_BASE_ENV = $$(PKG_PYTHON_SETUPTOOLS_RUST_ENV)
+else
 $(2)_BASE_ENV = $$(PKG_PYTHON_SETUPTOOLS_ENV)
+endif
 $(2)_BASE_BUILD_CMD = $$(PKG_PYTHON_SETUPTOOLS_CMD) build
 $(2)_BASE_INSTALL_TARGET_CMD = $$(PKG_PYTHON_SETUPTOOLS_CMD) install --no-compile $$(PKG_PYTHON_SETUPTOOLS_INSTALL_TARGET_OPTS)
 $(2)_BASE_INSTALL_STAGING_CMD = $$(PKG_PYTHON_SETUPTOOLS_CMD) install $$(PKG_PYTHON_SETUPTOOLS_INSTALL_STAGING_OPTS)
 else
+ifeq ($$($(2)_SETUP_TYPE),setuptools-rust)
+$(2)_BASE_ENV = $$(HOST_PKG_PYTHON_SETUPTOOLS_RUST_ENV)
+else
 $(2)_BASE_ENV = $$(HOST_PKG_PYTHON_SETUPTOOLS_ENV)
+endif
 $(2)_BASE_BUILD_CMD = $$(PKG_PYTHON_SETUPTOOLS_CMD) build
 $(2)_BASE_INSTALL_CMD = $$(PKG_PYTHON_SETUPTOOLS_CMD) install $$(HOST_PKG_PYTHON_SETUPTOOLS_INSTALL_OPTS)
 endif
-else ifneq ($$(filter flit pep517,$$($(2)_SETUP_TYPE)),)
+else ifneq ($$(filter flit maturin pep517,$$($(2)_SETUP_TYPE)),)
 ifeq ($(4),target)
+ifeq ($$($(2)_SETUP_TYPE),maturin)
+$(2)_BASE_ENV = $$(PKG_PYTHON_MATURIN_ENV)
+else
 $(2)_BASE_ENV = $$(PKG_PYTHON_PEP517_ENV)
+endif
 $(2)_BASE_BUILD_CMD = -m build -n -w
 $(2)_BASE_INSTALL_TARGET_CMD = $(TOPDIR)/support/scripts/pyinstaller.py dist/* $$(PKG_PYTHON_PEP517_INSTALL_TARGET_OPTS)
 $(2)_BASE_INSTALL_STAGING_CMD = $(TOPDIR)/support/scripts/pyinstaller.py dist/* $$(PKG_PYTHON_PEP517_INSTALL_STAGING_OPTS)
 else
+ifeq ($$($(2)_SETUP_TYPE),maturin)
+$(2)_BASE_ENV = $$(HOST_PKG_PYTHON_MATURIN_ENV)
+else
 $(2)_BASE_ENV = $$(HOST_PKG_PYTHON_PEP517_ENV)
+endif
 $(2)_BASE_BUILD_CMD = -m build -n -w
 $(2)_BASE_INSTALL_CMD = $(TOPDIR)/support/scripts/pyinstaller.py dist/* $$(HOST_PKG_PYTHON_PEP517_INSTALL_OPTS)
 endif
@@ -215,7 +255,29 @@ $(2)_BASE_BUILD_CMD = -m flit_core.wheel
 $(2)_BASE_INSTALL_CMD ?= $(TOPDIR)/support/scripts/pyinstaller.py dist/* $$(HOST_PKG_PYTHON_PEP517_INSTALL_OPTS)
 endif
 else
-$$(error "Invalid $(2)_SETUP_TYPE. Valid options are 'distutils', 'setuptools', 'pep517' or 'flit'.")
+$$(error "Invalid $(2)_SETUP_TYPE. Valid options are 'distutils', 'maturin', 'setuptools', 'setuptools-rust', 'pep517' or 'flit'.")
+endif
+
+# We need to vendor the Cargo crates at download time for pyo3 based
+# packages.
+#
+ifneq ($$(filter maturin setuptools-rust,$$($(2)_SETUP_TYPE)),)
+ifeq ($(4),target)
+$(2)_DL_ENV = $$(PKG_CARGO_ENV)
+else
+$(2)_DL_ENV = $$(HOST_PKG_CARGO_ENV)
+endif
+ifndef $(2)_CARGO_MANIFEST_PATH
+ifdef $(3)_CARGO_MANIFEST_PATH
+$(2)_DL_ENV += BR_CARGO_MANIFEST_PATH=$$($(3)_CARGO_MANIFEST_PATH)
+else
+ifneq ($$($(2)_SUBDIR),)
+$(2)_DL_ENV += BR_CARGO_MANIFEST_PATH=$$($(2)_SUBDIR)/Cargo.toml
+endif
+endif
+else
+$(2)_DL_ENV += BR_CARGO_MANIFEST_PATH=$$($(2)_CARGO_MANIFEST_PATH)
+endif
 endif
 
 # Target packages need both the python interpreter on the target (for
@@ -232,19 +294,35 @@ endif # ($(4),target)
 # Setuptools based packages will need setuptools for the host Python
 # interpreter (both host and target).
 #
-ifeq ($$($(2)_SETUP_TYPE),setuptools)
+ifneq ($$(filter setuptools setuptools-rust,$$($(2)_SETUP_TYPE)),)
 $(2)_DEPENDENCIES += host-python-setuptools
-else ifneq ($$(filter flit pep517,$$($(2)_SETUP_TYPE)),)
+ifeq ($$($(2)_SETUP_TYPE),setuptools-rust)
+$(2)_DEPENDENCIES += host-python-setuptools-rust
+endif
+else ifneq ($$(filter flit maturin pep517,$$($(2)_SETUP_TYPE)),)
 $(2)_DEPENDENCIES += host-python-pypa-build host-python-installer
 ifeq ($$($(2)_SETUP_TYPE),flit)
 $(2)_DEPENDENCIES += host-python-flit-core
 endif
+ifeq ($$($(2)_SETUP_TYPE),maturin)
+$(2)_DEPENDENCIES += host-python-maturin
+endif
 else ifeq ($$($(2)_SETUP_TYPE),flit-bootstrap)
 # Don't add dependency on host-python-installer for
 # host-python-installer itself, and its dependencies.
 ifeq ($$(filter host-python-flit-core host-python-installer,$(1)),)
 $(2)_DEPENDENCIES += host-python-installer
 endif
+endif
+
+# Pyo3 based packages(setuptools-rust and maturin) will need rust
+# toolchain dependencies for the host Python interpreter (both host
+# and target).
+#
+ifneq ($$(filter maturin setuptools-rust,$$($(2)_SETUP_TYPE)),)
+$(2)_DEPENDENCIES += host-rustc
+$(2)_DOWNLOAD_POST_PROCESS = cargo
+$(2)_DOWNLOAD_DEPENDENCIES = host-rustc
 endif # SETUP_TYPE
 
 # Python interpreter to use for building the package.