diff --git a/package/python-pillow/python-pillow.mk b/package/python-pillow/python-pillow.mk
index ab52f38df1..fd0c6ce862 100644
--- a/package/python-pillow/python-pillow.mk
+++ b/package/python-pillow/python-pillow.mk
@@ -59,8 +59,13 @@ endif
 ifeq ($(BR2_PACKAGE_WEBP),y)
 PYTHON_PILLOW_DEPENDENCIES += webp
 PYTHON_PILLOW_BUILD_OPTS += --enable-webp
+ifeq ($(BR2_PACKAGE_WEBP_DEMUX)$(BR2_PACKAGE_WEBP_MUX),yy)
+PYTHON_PILLOW_BUILD_OPTS += --enable-webpmux
 else
-PYTHON_PILLOW_BUILD_OPTS += --disable-webp
+PYTHON_PILLOW_BUILD_OPTS += --disable-webpmux
+endif
+else
+PYTHON_PILLOW_BUILD_OPTS += --disable-webp --disable-webpmux
 endif
 
 define PYTHON_PILLOW_BUILD_CMDS