diff --git a/package/mongrel2/mongrel2.mk b/package/mongrel2/mongrel2.mk
index 0be48327ac..d0640c9680 100644
--- a/package/mongrel2/mongrel2.mk
+++ b/package/mongrel2/mongrel2.mk
@@ -13,6 +13,21 @@ MONGREL2_LICENSE = BSD-3c
 MONGREL2_LICENSE_FILES = LICENSE
 MONGREL2_DEPENDENCIES = sqlite zeromq
 
+define MONGREL2_POLARSSL_DISABLE_ASM
+	$(SED) '/^#define POLARSSL_HAVE_ASM/d' $(@D)/src/polarssl/include/polarssl/config.h
+endef
+
+# ARM in thumb mode breaks debugging with asm optimizations
+# Microblaze asm optimizations are broken in general
+# MIPS R6 asm is not yet supported
+ifeq ($(BR2_ENABLE_DEBUG)$(BR2_ARM_INSTRUCTIONS_THUMB)$(BR2_ARM_INSTRUCTIONS_THUMB2),yy)
+MONGREL2_POST_CONFIGURE_HOOKS += MONGREL2_POLARSSL_DISABLE_ASM
+else ifeq ($(BR2_microblaze),y)
+MONGREL2_POST_CONFIGURE_HOOKS += MONGREL2_POLARSSL_DISABLE_ASM
+else ifeq ($(BR2_mips_32r6)$(BR2_mips_64r6),y)
+MONGREL2_POST_CONFIGURE_HOOKS += MONGREL2_POLARSSL_DISABLE_ASM
+endif
+
 define MONGREL2_BUILD_CMDS
 	$(TARGET_MAKE_ENV) $(MAKE1) $(TARGET_CONFIGURE_OPTS) -C $(@D) \
 		PREFIX=/usr all