diff --git a/package/strace/strace.mk b/package/strace/strace.mk
index 385c0029cc..59418af855 100644
--- a/package/strace/strace.mk
+++ b/package/strace/strace.mk
@@ -10,6 +10,14 @@ STRACE_SITE = http://downloads.sourceforge.net/project/strace/strace/$(STRACE_VE
 STRACE_LICENSE = BSD-3c
 STRACE_LICENSE_FILES = COPYING
 
+# strace bundle some kernel headers to build libmpers, this mixes userspace
+# headers and kernel headers which break the build with musl.
+# The stddef.h from gcc is used instead of the one from musl.
+ifeq ($(BR2_TOOLCHAIN_USES_MUSL),y)
+STRACE_CONF_OPTS += st_cv_m32_mpers=no \
+	st_cv_mx32_mpers=no
+endif
+
 define STRACE_REMOVE_STRACE_GRAPH
 	rm -f $(TARGET_DIR)/usr/bin/strace-graph
 endef