diff --git a/package/webkitgtk/webkitgtk.mk b/package/webkitgtk/webkitgtk.mk
index e5d591fcd2..cbd9003071 100644
--- a/package/webkitgtk/webkitgtk.mk
+++ b/package/webkitgtk/webkitgtk.mk
@@ -104,4 +104,13 @@ else
 WEBKITGTK_CONF_OPTS += -DUSE_GSTREAMER_GL=OFF
 endif
 
+# JIT is not supported for MIPS r6, but the WebKit build system does not
+# have a check for these processors. Disable JIT forcibly here and use
+# the CLoop interpreter instead.
+#
+# Upstream bug: https://bugs.webkit.org/show_bug.cgi?id=191258
+ifeq ($(BR2_MIPS_CPU_MIPS32R6)$(BR2_MIPS_CPU_MIPS64R6),y)
+WEBKITGTK_CONF_OPTS += -DENABLE_JIT=OFF -DENABLE_C_LOOP=ON
+endif
+
 $(eval $(cmake-package))