diff --git a/package/python-subprocess32/python-subprocess32.mk b/package/python-subprocess32/python-subprocess32.mk
index ee591e6a6b..fb8a47f974 100644
--- a/package/python-subprocess32/python-subprocess32.mk
+++ b/package/python-subprocess32/python-subprocess32.mk
@@ -11,4 +11,21 @@ PYTHON_SUBPROCESS32_SETUP_TYPE = setuptools
 PYTHON_SUBPROCESS32_LICENSE = Python-2.0
 PYTHON_SUBPROCESS32_LICENSE_FILES = LICENSE
 
+# The configure step needs to be run outside of the setup.py since it isn't
+# run correctly for cross-compiling
+define PYTHON_SUBPROCESS32_CONFIGURE_CMDS
+	(cd $(@D) && \
+	$(TARGET_CONFIGURE_OPTS) \
+	$(TARGET_CONFIGURE_ARGS) \
+	./configure \
+		--target=$(GNU_TARGET_NAME) \
+		--host=$(GNU_TARGET_NAME) \
+		--build=$(GNU_HOST_NAME) \
+		--prefix=/usr \
+		--exec-prefix=/usr \
+		--sysconfdir=/etc \
+		--program-prefix="" \
+	)
+endef
+
 $(eval $(python-package))