diff --git a/package/guile/Config.in b/package/guile/Config.in
index acb0974311..e93d3534ae 100644
--- a/package/guile/Config.in
+++ b/package/guile/Config.in
@@ -1,5 +1,6 @@
 config BR2_PACKAGE_GUILE
 	bool "guile"
+	depends on !BR2_TOOLCHAIN_USES_MUSL # no strtol_l
 	depends on BR2_TOOLCHAIN_HAS_THREADS
 	depends on BR2_PACKAGE_LIBATOMIC_ARCH_SUPPORTS # bdwgc
 	depends on BR2_USE_WCHAR # libunistring
@@ -15,7 +16,7 @@ config BR2_PACKAGE_GUILE
 
 	  http://www.gnu.org/software/guile
 
-comment "guile needs a toolchain w/ threads, wchar, dynamic library"
+comment "guile needs a uClibc or (e)glibc toolchain w/ threads, wchar, dynamic library"
 	depends on !BR2_TOOLCHAIN_HAS_THREADS || !BR2_USE_WCHAR || \
-		BR2_STATIC_LIBS
+		BR2_STATIC_LIBS || BR2_TOOLCHAIN_USES_MUSL