diff --git a/package/python-libconfig/Config.in b/package/python-libconfig/Config.in
index 7cc5f8a3cd..a222f9a130 100644
--- a/package/python-libconfig/Config.in
+++ b/package/python-libconfig/Config.in
@@ -1,5 +1,6 @@
-comment "python-libconfig needs a toolchain w/ C++, threads"
-	depends on !BR2_INSTALL_LIBSTDCPP || !BR2_TOOLCHAIN_HAS_THREADS
+comment "python-libconfig needs a glibc or uClibc toolchain w/ C++, threads"
+	depends on !BR2_INSTALL_LIBSTDCPP || !BR2_TOOLCHAIN_HAS_THREADS || \
+		BR2_TOOLCHAIN_USES_MUSL
 
 config BR2_PACKAGE_PYTHON_LIBCONFIG
 	bool "python-libconfig"
@@ -8,6 +9,8 @@ config BR2_PACKAGE_PYTHON_LIBCONFIG
 	select BR2_PACKAGE_LIBCONFIG
 	depends on BR2_INSTALL_LIBSTDCPP
 	depends on BR2_TOOLCHAIN_HAS_THREADS
+	# error: invalid use of incomplete type 'struct _IO_FILE'
+	depends on !BR2_TOOLCHAIN_USES_MUSL
 	help
 	  Python bindings to the C++ library libconfig