diff --git a/package/python-grpc-requests/Config.in b/package/python-grpc-requests/Config.in
index 3a2740f0f7..1cdd0d3f67 100644
--- a/package/python-grpc-requests/Config.in
+++ b/package/python-grpc-requests/Config.in
@@ -1,6 +1,7 @@
 config BR2_PACKAGE_PYTHON_GRPC_REQUESTS
 	bool "python-grpc-requests"
 	depends on BR2_PACKAGE_HOST_RUSTC_TARGET_ARCH_SUPPORTS # python-cryptography
+	depends on BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS # python-grpcio
 	depends on BR2_INSTALL_LIBSTDCPP # python-grpcio
 	select BR2_PACKAGE_PYTHON_CRYPTOGRAPHY # runtime
 	select BR2_PACKAGE_PYTHON_GOOGLE_API_CORE # runtime
@@ -12,4 +13,6 @@ config BR2_PACKAGE_PYTHON_GRPC_REQUESTS
 	  https://github.com/wesky93/grpc_requests
 
 comment "python-grpcio-requests needs a toolchain w/ C++"
+	depends on BR2_PACKAGE_HOST_RUSTC_TARGET_ARCH_SUPPORTS
+	depends on BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS
 	depends on !BR2_INSTALL_LIBSTDCPP
diff --git a/package/python-grpcio-reflection/Config.in b/package/python-grpcio-reflection/Config.in
index afe8988165..a0ca35c286 100644
--- a/package/python-grpcio-reflection/Config.in
+++ b/package/python-grpcio-reflection/Config.in
@@ -1,5 +1,6 @@
 config BR2_PACKAGE_PYTHON_GRPCIO_REFLECTION
 	bool "python-grpcio-reflection"
+	depends on BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS # python-grpcio
 	depends on BR2_INSTALL_LIBSTDCPP # python-grpcio
 	select BR2_PACKAGE_PYTHON_GRPCIO # runtime
 	select BR2_PACKAGE_PYTHON_PROTOBUF # runtime
@@ -9,4 +10,5 @@ config BR2_PACKAGE_PYTHON_GRPCIO_REFLECTION
 	  https://grpc.io
 
 comment "python-grpcio-reflection needs a toolchain w/ C++"
+	depends on BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS
 	depends on !BR2_INSTALL_LIBSTDCPP
diff --git a/package/python-grpcio/Config.in b/package/python-grpcio/Config.in
index 5242eb461e..9657ccb6ed 100644
--- a/package/python-grpcio/Config.in
+++ b/package/python-grpcio/Config.in
@@ -1,5 +1,15 @@
+config BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS
+	bool
+	# see third_party/boringssl-with-bazel/src/include/openssl/target.h
+	default y if BR2_aarch64 || BR2_aarch64_be
+	default y if BR2_arm || BR2_armeb
+	default y if BR2_i386 || BR2_x86_64
+	default y if BR2_mips || BR2_mipsel || BR2_mips64 || BR2_mips64el
+	default y if BR2_riscv
+
 config BR2_PACKAGE_PYTHON_GRPCIO
 	bool "python-grpcio"
+	depends on BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS
 	depends on BR2_INSTALL_LIBSTDCPP
 	help
 	  HTTP/2-based RPC framework.
@@ -7,4 +17,5 @@ config BR2_PACKAGE_PYTHON_GRPCIO
 	  https://grpc.io
 
 comment "python-grpcio needs a toolchain w/ C++"
+	depends on BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS
 	depends on !BR2_INSTALL_LIBSTDCPP