diff --git a/package/strace/strace.mk b/package/strace/strace.mk
index 5c2d33c5c3..78768489b9 100644
--- a/package/strace/strace.mk
+++ b/package/strace/strace.mk
@@ -12,6 +12,13 @@ STRACE_CONF_ENV = ac_cv_header_linux_if_packet_h=yes \
 		  ac_cv_header_linux_netlink_h=yes \
 	          $(if $(BR2_LARGEFILE),ac_cv_type_stat64=yes,ac_cv_type_stat64=no)
 
+ifeq ($(BR2_LARGEFILE),y)
+# strace gets confused when lfs mode is forced, so don't
+STRACE_CONF_ENV += \
+	CFLAGS="$(filter-out -D_FILE_OFFSET_BITS=64,$(TARGET_CFLAGS))" \
+	CPPFLAGS="$(filter-out -D_FILE_OFFSET_BITS=64,$(TARGET_CPPFLAGS))"
+endif
+
 define STRACE_REMOVE_STRACE_GRAPH
 	rm -f $(TARGET_DIR)/usr/bin/strace-graph
 endef