diff --git a/package/usbguard/Config.in b/package/usbguard/Config.in
index 34e24a2156..58ee5c4b25 100644
--- a/package/usbguard/Config.in
+++ b/package/usbguard/Config.in
@@ -5,6 +5,7 @@ config BR2_PACKAGE_USBGUARD
 	depends on BR2_TOOLCHAIN_HAS_THREADS # libqb, protobuf
 	depends on BR2_TOOLCHAIN_GCC_AT_LEAST_4_8 # protobuf
 	depends on !BR2_STATIC_LIBS # libqb, protobuf
+	depends on !BR2_TOOLCHAIN_USES_MUSL
 	select BR2_PACKAGE_PROTOBUF
 	select BR2_PACKAGE_LIBQB
 	help
@@ -16,7 +17,8 @@ config BR2_PACKAGE_USBGUARD
 
 	  https://usbguard.github.io/
 
-comment "usbguard needs a toolchain w/ C++, threads, dynamic library, gcc >= 4.8"
+comment "usbguard needs a glibc or uClibc toolchain w/ C++, threads, dynamic library, gcc >= 4.8"
 	depends on !BR2_INSTALL_LIBSTDCPP || !BR2_TOOLCHAIN_HAS_THREADS \
-		|| BR2_STATIC_LIBS || !BR2_TOOLCHAIN_GCC_AT_LEAST_4_8
+		|| BR2_STATIC_LIBS || !BR2_TOOLCHAIN_GCC_AT_LEAST_4_8 \
+		|| BR2_TOOLCHAIN_USES_MUSL
 	depends on BR2_PACKAGE_PROTOBUF_ARCH_SUPPORTS