diff --git a/package/gnuradio/gnuradio.mk b/package/gnuradio/gnuradio.mk
index d9218b533d..1453b78493 100644
--- a/package/gnuradio/gnuradio.mk
+++ b/package/gnuradio/gnuradio.mk
@@ -116,6 +116,9 @@ ifeq ($(BR2_PACKAGE_GNURADIO_PYTHON),y)
 GNURADIO_DEPENDENCIES += python3 python-pybind \
 	host-python-numpy host-python-packaging
 GNURADIO_CONF_OPTS += -DENABLE_PYTHON=ON
+# mandatory to avoid pybind11 to overwrite variables provided
+# by gnuradio and buildroot
+GNURADIO_CONF_OPTS += -DPYBIND11_PYTHONLIBS_OVERWRITE=OFF
 # mandatory to install python modules in site-packages and to use
 # correct path for python libraries
 GNURADIO_CONF_OPTS += -DGR_PYTHON_RELATIVE=ON \